Polarimeters measure the angle of rotation of optically active substances. Their measurement results are used for quality control in the production of active pharmaceutical ingredients and to check the identity of chiral substances in incoming and outgoing goods laboratories.
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Purity
Polarimeters can identify impurities by detecting changes in optical rotation.
Concentration
Polarimeters can measure the concentration of optically active substances in solutions.
Polarimeters can be used to measure the optical rotation of many substances, including:
Amino acids, Antibiotics, Dextrose, Steroids, Amino sugars, Cocaine, Diuretics, Tranquilizers, Analgesics, and Codeine.
The angle of rotation measured by a polarimeter is affected by the concentration of the sample, the temperature, the length of the observation tube, and the wavelength of the measurement.